Small RhombusA proven nonsurgical procedure that stimulates the body's natural healing processes to strengthen joints weakened by trauma or arthritis.

Prolotherapy Studies

Ann Auburn, DO, Scott Benjamin, PT, DScPT, & Roy Bechtel , PT, PhD, Prolotherapy for Pelvic Ligament Pain: A Case Report, Journal of Prolotherapy. 2009;2:89-95.

Background Content: This case study examines the effect of the addition of Prolotherapy to manual therapy, and pelvic and trunk exercises, in a treatment regime for a patient with pelvic and chronic low back pain (CLBP) who had previously failed manual therapy and exercise alone and in combination. We hypothesized that with continued exercise and the combination of Prolotherapy and manual therapy, there would be better improvement than any single intervention to reduce pain and improve stability in the lumbar spine and pelvis. Purpose: The purpose of our case study was twofold.

  1. If the tenderness in the above ligaments would be reduced using the combination of Prolotherapy, therapeutic exercise, and manual therapy.
  2. Whether our subject would show functional improvement after treatment.

Study Design: Single case study.
Methods: One subject, a 44 year-old male with a history of left L5-S1 laminectomy and ligamentous laxity in the pelvis and sacral ligaments, was assessed and treated by the primary author, using Prolotherapy and manual therapy. Therapeutic exercise was performed five days a week with an emphasis on the pelvic and deep trunk stabilizers.
Results: After treatments, the patient demonstrated less tenderness, improved ligamentous stiffness, and displayed improved pelvic joint stability. Function also improved as measured by his ability to work, exercise, and perform home activities with less stiffness and pain than previously noted.
Conclusion: Patients with LBP may benefit from Prolotherapy to aid in reducing pelvic and lumbar instability in conjunction with manual therapy and exercise to improve dynamic pelvic stability.


Br J Sports Med 2010;44:100-104 doi:10.1136/bjsm.2007.042044 The use of prolotherapy in the sacroiliac joint M Cusi1, J Saunders2, B Hungerford3, T Wisbey-Roth4, P Lucas2, S Wilson1

OBJECTIVE: In this study the effectiveness of prolotherapy in the treatment of deficient load transfer of the sacroiliac joint (SIJ) was determined.
DESIGN: A prospective descriptive study.
SETTING: Authors’ private practice.
PARTICIPANTS: 25 patients who consented to treatment and attended for at least one follow-up visit and assessment.
STUDY PERIOD: From April 2004 to July 2007.
INTERVENTION: Three injections of hypertonic dextrose solution into the dorsal interosseous ligament of the affected SIJ, under CT control, 6 weeks apart.
MAIN OUTCOME MEASURES: Quebec Back Pain Disability Scale, Roland–Morris 24, Roland–Morris 24 Multiform questionnaires and clinical examination by two authors independently.
RESULTS: All patients included in this study attended at least one follow-up visit at 3, 12 or 24 months.. The number of patients at follow-up decreased at 12 and 24 months. Functional questionnaires demonstrated significant improvements for those followed-up at 3, 12 and 24 months (p<0.05). Clinical scores showed significant improvement from commencement to 3, 12 and 24 months (p<0.001).
CONCLUSIONS: This descriptive study of prolotherapy in private practice has shown positive clinical outcomes for the 76% of patients who attended the 3-month follow-up visit (76% at 12 months and 32% at 24 months). Similar results were found in the questionnaires (Quebec Back Pain Disability Scale, Roland–Morris 24 and Roland–Morris 24 Multiform questionnaires) at 3, 12 and 24 months.


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